BioGenes offers the development of anti-idiotypic polyclonal antibodies (specific anti-drug-antibodies) in rabbits and goats.
Depending on the required quantity of purified polyclonal anti-IDs, the species, the number of animals as well as the immunization schedule will be selected
(from a 28-day protocol with one bleed up to a 105-day protocol with four bleeds).
Polyclonal anti-IDs are typically used as positive control in immunogenicity assays for the safety assessment of therapeutic antibodies.
SDS-PAGE of the antigen for quality control
Testing of pre-immune sera for selection of suitable animals
Immunization according to the agreed number of animals and immunization schedule
Quality control of antisera and purified antibodies using ELISA
Isolation of specific IgGs with subsequent anti-human-IgG antibody depletion by affinity purification
The animals can be kept after delivery of the antibodies for as long as necessary